| 名稱 | CD40/CHO |
| 型號(hào) | CBP74034 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | CD40/CHO，凍存條件：90% FBS+10% DMSO |
產(chǎn)品搜索
相關(guān)文章
- BCMA靶點(diǎn)藥物細(xì)胞篩選模型
- ATCC細(xì)胞株開發(fā)的四階段簡介
- 聚焦靶點(diǎn)BRAF——BRAF相關(guān)突變細(xì)胞強(qiáng)勢(shì)登場(chǎng)
- 從《指導(dǎo)原則》中分析參考品盤設(shè)計(jì)
- 【分享】NIST開發(fā)ERBB2- CNV標(biāo)準(zhǔn)品的一些思路
- 【連載-企業(yè)參考品】胃癌的診斷參考品的選擇
- 新型冠狀病毒：用于診斷的假病毒標(biāo)準(zhǔn)品和用于藥物研發(fā)的假病毒模型
- 【產(chǎn)品推介】GLP1藥靶模型
- TSLP靶點(diǎn)藥物細(xì)胞篩選模型
- atcc細(xì)胞培養(yǎng)紫外燈照射的目的與實(shí)踐
聯(lián)系我們
聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74034CD40/CHO
- 詳細(xì)內(nèi)容
| CBP74034 | |
| I. Background | |
| CD40, a TNF receptor superfamily member, was initially identified on B lymphocytes. However, other cell types such as monocytes, basophils, dendritic cells, endothelial cells, and epithelial cells have been found to express CD40. High levels of CD40 have also been detected in numerous human cancers, including HCT116, a colon cancer epithelial cell line. Interaction with CD40 ligand (CD40L, CD154) on CD4+ T helper lymphocytes triggers the expression of intercellular adhesion molecule (ICAM) and other pro-inflammatory cytokines. CD40:CD40L signaling simultaneously increases activation of antigen-specific T cells. CD40 also activates NF-κB-dependent signaling in response to lipopolysaccharide (LPS) found on Gram negative bacterial pathogens. Agonistic CD40 monoclonal antibodies have been shown to activate antigen presenting cells (APC), promote anti-tumor T-cell responses, and to foster cytotoxic myeloid cells, suggesting a potential mechanism to control cancer in the absence of T-cell immunity. | |
| II. Description | |
Recombinant CHO cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5; TNFRSF5), Genbank Accession No. NP_001241.1. | |
| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | CD40 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12k+10%FBS+5ug/ml puromycin |
| Application(s): | Binding Assay,FACS |
| Storage: | Liquid nitrogen |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
 | |
Figure 1. Recombinant CHO cell line expressing full length human CD40. | |
會(huì)員_a.png)